For more background info, check out my post onPGS Testing. I was completely devastated because I never thought that would happen with a PGS. Ill also update this blog to include that info. Looking for anyone who has had recurrent chemical pregnancies and then found success. A pregnancy that doesn't even make it to the 6 week scan where they can usually see the fetus on an ultrasound. We were hoping for a Christmas miracle however that was short lived. Oops, meant to say Im 17 weeks pregnant from my last FET! However, that information will still be included in details such as numbers of replies. wow, Im so glad you were able to get a second opinion. frustration and tears were worth it. Thanks! For more up-to-date information on this topic check out my other posts that are tagged withPGS (PGT-A) success rates. Patient(s): Cases included 38 patients who underwent frozen euploid ET as determined by aCGH, resulting in miscarriage. So most <35 women are between 30-90% chance ofeuploid(61% is the average). For that reason my RE said she would start testing such as ERA after a second failed transfer but didnt think it was necessary after the first failed transfer. Im so sorry to hear about your losses but so happy with your current miracle. See the chart below from the CDC (2016 data): In this post well look at the different miscarriage rates that all these types of PGT-A tested embryos have. Why did I miscarry a normal embryo? A doctor can confirm it by testing blood for human chorionic gonadotropin (hCG . I am remaining hopeful, when we sent our embryos for testing, they only thought that one would come back normal. Is there any reasoning behind this- is it due to poor egg quality, poor sperm quality, or both? Segmental mosaics or single chromosome mosaics tend to perform better than multiple chromosome abnormalities which can approach 50% miscarriage rates. Nov 2016-IVF #2 16 eggs -> 3 PGS-normal embryos Jan 2017-single FET #2: BFN . The chances of having a positive outcome with PGS testing and IVF depend on the number of the produced embryos that have a positive result in the test. Group Black's collective includes Essence, The Shade Room and Naturally Curly. Did your RE have you take anything other than progesterone and estrogen and aspirin? Reminder: I have an integrated glossary in the text (terms are underlined with a dotted black line, and when you tap on it a window will pop up with the definition). I'm curious if this might have something to do with it. For the autoimmune stuff above I was tested by Alexander Kofinas. Fast Facts About PGS Testing Risks. Congratulations on your success , I have a similar story. I feel so lucky that I found this community. I can't tell if that is from the progesterone. A 2019 multicenter and international RCT (the STAR trial) compared euploid and untested embryo transfers. While those are great odds, sometimes the FET fails. I'm super bummed about it being a chemical, but I still feel like progress was made because this was my first positive pregnancy test EVER. Check mycomplete guide to mosaic embryosto learn more about mosaics, or mycomplete guide to PGT-Ato get more background on PGT-A (akaPGStesting). I would Love and Need your opinions on this. Ill come back and edit this post with the link. I know PGS tested embryos can still have issues but its been 4 transfers now with no success so Im wondering if theres a deeper issue. Can I ask why they didn't test them on Day 5? I would like to use the delestrogen shots next time instead of the patches and pills which seem to do nothing for me. Hi Mogwai_2 Theses are rates for PGS normal embryos. Are there recent numbers for this comparison? Of course the quality of the embryo is everything but there is significantly more uterine prep with a frozen transfer and I think it helped. As for boosting chances with two put back it should not be the trick. My first FET failed and it was devastating. However, the two transfers we did werent PGS tested. For more up-to-date information on this topic check out my other posts that are tagged withEmbryo rebiopsy. (2017)found a reduction in embryo survival (from 98% to 93%) and a reduction inlive birth rate(50% to 27%). So I tried to find information through the site because I know topics like this have been posted before, BUT when I pull the results somehow PGS results in a whole lot of pregnancy posts as pg is used as a shortcut, and I am so all set with that. The protocol was exactly the same as with the chemical pregnancy with addition of baby aspirin. My husbands sperm analysis was only very slightly abnormal. Going into my second round of IVF I was doubting anything would work. Best of luck to you. When questioned as to why nothing was working, his response was sometimes it just doesnt happen and we dont know why. IVF/ICSI #3 another chemical with two frozen embryos left over. Aww happy your second round worked! Or is that the reason they don't continue to progress? Did your doctor have your SO go through the rounds of antibiotics as well? Or is it worth having the actual tests done? Very frustrating to have an inconclusive. A few rounds of heavy- duty antibiotics cleared it up. My dr never mentioned anything regarding epigenetic issues. But if you dont like the extra meds you could talk with your current or new clinic about not doing it and get their thoughts on it. There is much better chance of IVF success with PGS testing in women who were over the age of 35. Turns out I was 24 hours prereceptive and Im convinced the ERA and extra day of progesterone is what did it. If your window is off I would think that could cause chemical pregnancies because the embryo would have a hard time implanting. It worked and now I'm 24 weeks pregnant with twins! If it's any consolation, we also did acupuncture with the failed FET, but not the one that worked. Would love to hear if it was successful - fingers crossed . Mosaics are embryos that have a mix of euploid and aneuploid cells. Hi.all0130could you tell me what kind of endometrial scratch biospy you did?hi.T3bk.you did endometrial scratch biospy too?which one you did?era.yale eft.or something else? She was also concerned with the previous doctors aggressive surgery protocols, and my age was also a factor. Its not a ton of time to do and it might make the difference. I actually didnt have embryos to bring with me when we switched. Its very disheartening though. Its such a good point and one that is often missed, I think. Do embryo biopsies for PGT-A match the rest of the embryo? MENTS my 3rd FET was a success end MENTS. Mosaic embryos can be either low- or high . Just thought Id throw this test out there though! I did not do an ERA although I know a lot of people who have and have gathered helpful info from it. Note: I'm also doing a pregnancy loss blood panel to investigate clotting, and am looking into autoimmune causes as well. thank you for sharing! Group Leaders arent expected to spend any additional time in the community, and are not held to a set schedule. Genetic testing was normal. Nov 2, 2016 8:12 AM. With both transfers I did estrogen tablets, progesterone in oil shots, blood thinner shots and low dose aspirin. Normally, we have 23 pairs of chromosomes (or 46 in total) one pair comes from the egg from our biological mother, and the other comes from the sperm from our biological father. I am thinking of you and truly wish you the best in January , Im sorry for a late response Ive been off the app to work on my mental health. If I had transferred two without PGS, there would have been a significant chance that both would have been abnormal. So maybe youve had a cycle and your embryos are frozen, and now you want them biopsied. We did do some things differently, however my RE did these things more to appease me because he knew how frustrated I was than because he thought they were medically necessary. Im going to try and run it by her again to see what she thinks. Your experience is so inspiring, thank you for sharing . Because of my age and being diagnosed with diminished egg reserve we did "embryo batching" and I had 4 rounds of egg retrievals before moving onto any transfers. What to Expect supports Group Black and its mission to increase greater diversity in media voices and media ownership. So, all is well! My RE felt that having one good embryo was not a guarantee, so 4 rounds of retrievals it took before we had a few to work with. My first FET was a day 6 5AA euploid embryo. I honestly wish I had but thats all hindsight now knowing what I knew. Took 2 years of "fighting" but looking back all the money, pain. I am 41 years old. Check here for the full glossary (please excuse the repeated terms!). We had 4 blasts tested in our first IVF cycle and 2 were abnormal / 1 mosaic / and then 1 "normal". Question about blastocysts and PGS testing - we got 12 eggs / 7 mature / 7 fertilized with ICSI and 2 grew to 6 days. I have however done Intralipid Infusions and taken Neupogen beginning a week before transfer for Autoimmune protocol (although Ive never actually been tested for Autoimmune disorder). Second, PGS speeds up the time to pregnancy. My result came with a high risk, 1 in 11 chances of the baby having Down Syndrome. Zhao et al. Next Generation Sequencing (NGS) is a new technique which boasts an impressive 99.98% consistency rate for its results. Im trying not to fixate on my last embryo being a day 7. Embryoman (Sean Lauber) is a former embryologist and creator of Remembryo.com. I hope this helps. I know Im my heart I want to try again, but my brain is working overtime too - odds, finances, and the risk of suffering all over again, Im so sorry to hear all this! If it were me and it was my last embryo I would definitely ask about (possibly even push for) immune protocol and the ERA just to cover all my bases. It kind of makes me wonder what they get out of their alternative recommendations. I guess I'm facing wasting the investments of stimulation vs potentially wasting the investments in proceeding but also getting more information that might help with future cycles. We had two from #4 cycle- one normal boy embryo and another that they said they didn't have enough material to test. Terms are highlighted every 3rd time to avoid repetition. Consult with your doctor before making any treatment changes. I have a similar story. We have our lining check on Friday. We started some workup with my OB (TSH, karyotyping and carrier testing). Trying naturally, assisted, etc. Is it significantly less for a pregnancy with an embryo that tested pgt normal? 2014). I could tell that my dr thought we could just try again but she knew I needed to check something to feel ok with it. At least testing a few variables like blood clotting. He earned his MSc in 2012 for his research on inflammation and lung cancerand started Remembryo in 2018 to help people understand the evidence behind common IVF topics. , ERA was a game changer for me! Did testing and just found out it was a triploid embryo so it had 69 chromosomes. At this point I am wondering the following: what were the extra things you did besides Lovenox/prednisone, biopsy and ERA? Dr is responsible for allowing . I know this is an incredibly hard time and it's a tough decision- best of luck to you- don't give up hope. Does this harm the embryo or reduce its potential for success? He provides weekly summaries of the latest IVF research and posts on Facebook, Instagram and TikTok regularly. Single embryo transfer both times. How did your pregnancy turn out? I was put on the Schoyer protocol for stimulation. What to Expect supports Group Black and its mission to increase greater diversity in media voices and media ownership. You got this! I was exactly like you- I told myself and my RE that I refused to go through that devastation again so I wanted to do everything possible to make the outcome different. First, PGS improves pregnancy rates. We did accupuncutre 2x a week prior to transfer and a pre/post on transfer day as well. I pay completely out of pocket for everything so the added expense was not something I wasnt looking forward to, but Im happy I went through with it. Recurrent Chemical Pregnancy - PGS embryo (and Donor egg ) Advice needed. I refused to go into another FET without doing some test or adjusting 1 variable, otherwise it was just repeating the same mistakes in my mind. According to the authors, the >35 group analysis should be interpreted with caution as the sample size was small. A Group Owner is a member that has initiated the creation of a group to connect with other members to share their journey through the same pregnancy & baby stages. It wouldnt be going far at least. definitely worth asking! Best of luck to you. 12 43 comments Best Add a Comment gundacurry 2 yr. ago https://www.fertstert.org/article/S0015-0282 (17)31371-7/fulltext lennylincs 2 yr. ago Any advice is greatly appreciated. This test can identify chromosomally normal embryos, which increase the chances of a healthy pregnancy. 144 abnormal (aneuploid/mosaic) embryos and their outcomes. Please whitelist our site to get all the best deals and offers from our partners. Do the birth success rates of pgs tested embryos include both those that get a positive pregnancy test and those that dont? We found out yesterday we were having a chemical pregnancy, my second beta didnt double. An embryo forms and may even embed in your uterus lining (implantation), but then it stops developing. TTC 3 years I cried the whole way home. If your protocol did not have one or the other perhaps you can ask your RE about it. You said that The per retrieval statistic helps to see the chances before PGS testing. But it almost seems like there should be another set of statistics for better putting success rates into perspective. Good luck and wishing baby dust your way soon! MENTS I am also going through a chemical pregnancy this week, but with an untested embryo (so, that's very likely the reason for my loss). After 10 days, they came back and said that it was low and that i should mentally prepare myself for a chemical pregnancy. I know how hard this all is. Good luck and dont give up on hope yet! It is seriously invaluable to me. They also reported the number ofblastsbiopsied. I know in our case our embryos had epigenetic issues which meant that our baby that we miscarried probably had structural issues. is there another clinic in your area you can switch to? I just looked briefly online and saw mixed reviews about embryos being damaged when shipped. I have expressed my concern but my RE believes it is more about the pattern. I actually didn't do acupuncture the second cycle, but I was in great shape. Miscarriage is defined as a loss between clinical pregnancy (detection of a gestational sac or heartbeat) and 20 weeks of gestation. I am 42. I know how devastating loss can be but theres always, always hope. Generally, Day 5 embryos perform better than Day 7 embryos. Disclaimer: Any studies presented here may be contradicted by other studies. The only thing different medication wise was that I took a baby aspirin once daily starting the day of transfer the second time. Saw a heartbeat at 6 and 8 weeks then nothing at week 10. To perform the biopsy, an embryologist removes 2-10 cells from the precursor placenta cells of the blastocyst embryo, called the trophectoderm. Im assuming you had no issues shipping yours? When we started I was told by an RE I had a 2% chance of having a baby with my own eggs. Definitely heartbroken but trying to look forward. I just wish we had more answers so we can prepare for the next . However, almost all studies and clinic data show that IVF success rates indicates higher pregnancy rates. Weve spent almost 45K on this process and we are with a reputable clinic affiliated with CCRM so I am confident they know what they are doing but you cant also help but wonder is there more that can be done Im waiting to hear from the team to see if shes given some more thoughts. Does PGT-A reduce the chances of miscarriage? All that to say, it's likely that there actually was something wrong with that embryo - but it's worthwhile to leave no stone unturned before trying again. In the past PGS was seen as the holy grail - if the chromosomes are normal we should have implantation and a normal pregnancy. With the retrieval statistics, we can include all cycles (like the ones that ended with no blasts to transfer or only abnormal embryos that werent transferred) and that lowers the success rates quite a bit. My doctor really only wants me to transfer one embryo, my husband and I want to do 2. Congratulations on your pregnancy xxx RPL and endomitritis biopsy isnt a new thing, and its the same procedure as an ERA (which I also highly recommend). I feel like most times the protocol for autoimmune issues is the same. PGT-A (formerly PGS testing) is a technique that determines the number of chromosomes in the cells of an embryo. He provides weekly summaries of the latest IVF research and posts on Facebook, Instagram and TikTok regularly. The psychologist who ran the group, who also happened to be an RE at my fertility clinic, explained that sometimes you have a seemingly perfect embryo, perfect uterine lining, and the FET just fails. I hope this gives you some hope. Can you tell me the success rate? Terms are highlighted every 3rd time to avoid repetition. The thing we did differently for this one was adding an antihistamine protocol. Terms are highlighted every 3rd time to avoid repetition. PGT-A is generally recommended for women >35, and the majority of cycles in the US in 2020 were for women >35 (62%). And demand that my lining be over 8 before I allow another transfer to occur? We decided to see an RE given our age. Interestingly enough my protocol remained the same between my chemical FET and the successful one. Have they tried changing your protocol (ie from natural to artificial cycle)? Statistically speaking it takes an average of two transfers before a successful pregnancy. Thanks again! So crazy that its what finally worked. You can check out my summary of the study here. She says that with PGS tested embryos my rate to achieve pregnancy is 70% and a twin pregnancy is at 50%. Your post will be hidden and deleted by moderators. I just wanted to know if anyone had a similar experience and if you can share the things you did differently with your second transfer and had success? We decided to start with IUI with clomid which resulted in another chemical pregnancy. Trying to be strong and not make the holidays about my loss for the sake of my family, not sharing the news either until after. Viotti et al. thank you for sharing your success story! My lining a week before transfer was 6.8, but trilaminar lining was present. Disclaimer: Any studies presented here may be contradicted by other studies. How about a mosaic? Thanks! I am so frustrated and emotional, I am not having any pregnancy symptoms, beside some minor vaginal cramping and sore breast. That sounds a lot like my dr. Its basically an assembly line in there. Did you do anything different with your FET? Comprehensive Chromosome Screening (CCS) is one technique of PGT-A that can identify whether an embryo is XX (female) or XY (male). We have not done a hysteroscopy but will ask my dr if we can do one to check and at least rule that out. Be sure to read the next two sections to get an idea of how grades and growth rates (Day 5, 6, 7) affect IVF with PGS success rates, as well as this section further down. Thanks for commenting! Try to take extra good care of yourself while you regroup from this cycle, and then go with your instincts for your next cycle. I'm doing the full "recurrent pregnancy loss" blood workup and karyotype genetic testing on my husband and me before we try again. To do PGT-A, a sample of cells (a biopsy) is taken from the embryo and is submitted for DNA testing in a separate lab. Don't lose hope! (2018)found a slight reduction inlive birth ratecompared to single biopsied embryos (50% vs 58%), but this was notstatistically significant. Learn more about, Learn About What to Expect's Pregnancy & Baby App. I didnt realize you could transfer your embryos to another clinic. Do you think it's worth it as last time I had a medicated cycle and it was a . Or a fully aneuploid embryo? Other studies seem to suggest a 8-11% chance of miscarriage with a euploid transfer. Neal et al. Ive had two biochemical losses with day 6 4BC euploids and with 1 day 6 4BC left to try, Im wondering our odds. Create an account or log in to participate. The usefulness comes when someone who is starting IVF and considering PGS testing. What would they tell me and how would they impact protocol differently? Well start with euploids, then mosaics, and end with fully aneuploid embryos. Best of luck to you!! MENTS We were devastated after our first pgs transfer ended in a chemical, and unfortunately we went on to have one more before finding success. no, I just took those 3. Infertility Support Community in Partnership with RESOLVE. We spent well over 45K to get to this point. If you want to read more about rebiopsying embryos, check out my archives for embryo rebiopsy. We respect everyones right to express their thoughts and opinions as long as they remain respectful of other community members, and meet What to Expects Terms of Use. Reply Share React AMB425 Sep 2, 2016 11:01 AM Please don't give up! Consult with your doctor before making any treatment changes. There isnt much data on it, and 2 of the 3 studies found no difference, so it isnt exactly clear. Note that once you confirm, this action cannot be undone. I know it only takes one good embryo to be successful and I understand the odds of having a good enough embryo to send for testing and having that testing turn out normal is very small. And I can't say thats the sole reason this one stuck, but it is the one thing we did differently, and here I am. We are so happy about that, we just want this one to be the one. Besides that, there are no gaurantees of both sticking. This can be done! They did blood tests after my miscarriage and my doctor said it was important to do it when my body still thought I was pregnant. 2 - IUIs both chemical If you feel a message or content violates these standards and would like to request its removal please submit the following information and our moderating team will respond shortly. (2014)found no difference inongoing pregnancieswith Day 5 or 6 euploids (about 50%). I know Ive had issues with my lining but for each of the chemical pregnancies we were able to get my lining to at least 8mm with a mixture of puregon and cetrotide injections, instead of estrace, as well as PRPs. I also know that no one can make this decision for me. Might be worth asking about. Check out mycomplete guide to embryo grading and success ratesto learn more about embryo development, grading and success rates. I am hoping number 5 is it. Weve discussed euploid embryos, mosaic embryos, so what about aneuploid embryos? Its good you will request the endomitritis biopsy. I also stopped working night shifts (Im a nurse) to reduce my stress levels but that didnt help either. This educational content is not medical or diagnostic advice. I know that every cycle + embryo is different, but it's so hard to not compare cycles. Hi lovely people , as per your recommendations I went for another egg retrieval and did pgs testing on 3 embryos out of which 2 came back normal. 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