1982;35(2):471-475. Antimicrobial Agents and Chemotherapy 1988;32(9):1370-1374. Expert.Opin.Investig.Drugs 2005;14(5):683-685. View abstract. Pharmacy Times. Seow WK, Ferrante A, Summors A, and et al. A., Maciel, B. C., Secches, A. L., and Gallo, Junior L. Cardiovascular effects of berberine in patients with severe congestive heart failure. A clinical study on the short-term effect of berberine in comparison to metformin on the metabolic characteristics of women with polycystic ovary syndrome. Marin-Neto, J. B. Berberine, a natural plant product, activates AMP-activated protein kinase with beneficial metabolic effects in diabetic and insulin-resistant states. Therefore, more studies are needed before strong conclusions can be made. However, theres also evidence that goldenseal may help your body get rid of certain drugs more quickly through the urine. It's thought to work through these chemicals. Today . View abstract. Annals of Tropical Medicine and Parasitology 1991;85(4):417-425. These compounds may also reduce inflammation, which further explains how they may help with digestive discomfort and symptoms of the common cold, like sore throat. Because of this, some believe goldenseal may help hide the use of illegal drugs to pass a drug test (1). 2007;57:26-30. Fukuda K, Hibiya Y, Mutoh M, et al. Gupte S. Use of berberine in treatment of giardiasis. May Help Prevent Urinary Tract Infections, The compound berberine may prevent bacteria from sticking to the lining of the urethra and bladder, preventing urinary tract infections (UTIs.) View abstract. Calendula. In Vivo 2005;19(1):247-252. View abstract. Using this as a mouth rinse cures my canker sores within 24 hours, even one that became infected. View abstract. Most of the health benefit claims about goldensealare anecdotal or based on traditional medicinal practices, and have not been sufficiently evaluated in a medical setting. Gen Pharmac 1979;10:177-182. Select a condition to view a list of vitamins. (7), Some people also use it for stomach swelling (gastritis), peptic ulcers, ulcerative colitis, diarrhea, constipation, hemorrhoidsand intestinal gas. Learn about different types and treatments of urinary tract infections, the risk factors, and prevention for both men and women. Life Sci 1998;62(25):2283-2294. This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. Finally, goldenseal may interact with certain medications, including antidepressants. (9), There havent been any clinical (human) studies to date, but goldenseal is also sometimes recommended to treat urinary tract infections (UTIs), which are caused by bacterial overgrowth in the bladders interior walls. J AOAC Int. View abstract. For any of these concerns, a goldenseal mouth rinse can help by reducing inflammation and getting rid of any nasty bacteria. Butcher NJ, Minchin RF. J Indian M A 1970;54(1):22-24. Inhibition by berberine of cyclooxygenase-2 transcriptional activity in human colon cancer cells. Babbar, O. P., Chhatwal, V. K., Ray, I. Goldenseal can provide health benefits like: Goldenseal is a common ingredient in herbal eyewashes to help with itchiness from seasonal allergies or discomfort from eye infections. ", National Organization for Rare Disorders: "Kernicterus. Supplementation with goldenseal (Hydrastis canadensis), but not kava kava (Piper methysticum), inhibits human CYP3A activitiy In Vivo. If you have difficulties swallowing pills, goldenseal might also be available in other dosage forms, which may include: There may also be vegan and vegetarian options. Therefore, they may be expected to have effects and side effects that are different than those of goldenseal. Moreover, due to its high cost, some products claiming to contain goldenseal may not contain any amount of this plant or very little of it. View abstract. Int J STD AIDS. Ivanovska N and Philipov S. Study on the anti-inflammatory action of Berberis vulgaris root extract, alkaloid fractions and pure alkaloids. Zeng, X. and Zeng, X. For instance, some products replace goldenseal with Chinese goldthread, Oregon grape root, barberry, yellow root, or Chinese goldenseal all of which contain berberine but no hydrastine or canadine (50). Although these results seem promising, theres currently no scientific proof that goldenseal produces the same effects. Avoid putting unused and expired medicines down the drain or in the toilet. Although the results from this study seem promising, no human studies have directly examined the effect of goldenseal on UTIs or yeast infections to date. Clinical trial of high-dose berberine and tetracycline in cholera. Goldenseal has been utilized as an eyewash for eye inflammation and eye infections like conjunctivitis or pink eye. Since the use of it in the eyes is somewhat controversial, consult a health care practitioner before using it in this way. View abstract. Wang, Y., Jia, X., Ghanam, K., Beaurepaire, C., Zidichouski, J., and Miller, L. Berberine and plant stanols synergistically inhibit cholesterol absorption in hamsters. Nat Med 2004;10(12):1344-1351. Gurley BJ, et al. View abstract. Learn about URI causes, treatment, and prevention. View abstract. These complementary and alternative medicine books will teach you the ins and outs of topics such as Ayurveda, essential oils, and Chinese medicine. Clin.Cardiol. Acetaldehyde-induced interleukin-1beta and tumor necrosis factor-alpha production is inhibited by berberine through nuclear factor-kappaB signaling pathway in HepG2 cells. Berberine is a compound found naturally in many plants. Yet, fortunately there is research to support the medicinal use of it. The information in our articles is NOT intended to replace a one-on-one relationship with a qualified health care professional and is not intended as medical advice. Goldenseal supplements are available in a wide range of forms, including capsules, lotions, drops, sprays, eyewashes, and feminine hygiene products. A biochemical study on the hypotensive effect of berberine in rats. Clinical trial of berberine in acute watery diarrhoea. In fact, results from a small clinical trial suggest that topical berberine may relieve canker sore symptoms. View abstract. Examples of CYP3A4 substrates may include Zocor (simvastatin) for high cholesterol and cyclosporine or Prograf (tacrolimus) to prevent organ transplant rejection. Taking goldenseal with metformin might decrease the effects of metformin. Breastfeeding: The NCCIH recommends against goldenseal while breastfeeding. However, it is not clear if this interaction is serious enough to reduce the effects of oseltamivir. Iizuka, N., Miyamoto, K., Okita, K., Tangoku, A., Hayashi, H., Yosino, S., Abe, T., Morioka, T., Hazama, S., and Oka, M. Inhibitory effect of Coptidis Rhizoma and berberine on the proliferation of human esophageal cancer cell lines. Jantova, S., Cipak, L., Cernakova, M., and Kost'alova, D. Effect of berberine on proliferation, cell cycle and apoptosis in HeLa and L1210 cells. Pharmacol Toxicol. A single-blind clinical investigation. Mikkelsen SL and Ash KO. However, research on this topic is limited and not specific to goldenseal. 1994;14(12):718-720. View abstract. A comparative study on the hepatoprotective action of bear bile and Coptidis Rhizoma aqueous extract on experimental liver fibrosis in rats. View abstract. Native Americans historically used goldenseal for various health concerns including skin diseases, ulcer symptomsand gonorrhea. Asher GN, Corbett AH, Hawke RL. Int J Immunopharmac 1996;18(10):553-561. This Dr. Axe content is medically reviewed or fact checked to ensure factually accurate information. Some people may use goldenseal for canker sores (ulcers in the mouth). In vivo research has also been performed on a series of human malignant brain tumor cells and rat brain tumor cells in which berberine was used alone at a dose of 150 mcg/ml and had an average cancer cell kill rate of 91 percent. 1988;11(4):253-260. However, little is known about its effects in children, other than that it may cause or worsen jaundice in newborns. But like many natural products, people may use goldenseal for various reasons. Due to over-harvesting, it is now mostly commercially grown on farms in the U.S. Goldenseal plants have hairy stems withfive to seven jagged, lobed leaves and small white flowers that turn into raspberry-like red berries. Studies suggest that berberine, one of the main compounds in goldenseal, may reduce sugar absorption from the gut, lower insulin resistance, and promote insulin secretion all of which are factors that may help lower blood sugar levels (46). Immune System There are quite a few active ingredients in goldenseal tea that prevent bacterial and viral infections, including a high concentration of alkaloids, protecting us against common respiratory and . of North America growing from southern Quebec to northern Georgia and west to Missouri. ", Photochemistry and Photobiology: "Photochemistry and Photocytotoxicity of Alkaloids from Goldenseal (Hydrastis canadensis L.) 3. Am J Chin Med 1999;27(2):265-275. 2013;115(2):212-217. doi: 10.1016/j.oooo.2012.09.009, Pang B, Zhao LH, Zhao Q, et al. Taking goldenseal may change the way your body processes medication. Beneficial effects of berberine on left ventricular function in dogs with heart failure. View abstract. Vik-Mo, H, Faria DB, Cheung W, and et al. View abstract. Theres currently little to no research regarding the safety of goldenseal use in pregnant or breastfeeding women. Additionally, when only berberine was given, hospitalizations for diarrhea were shorter. They are antimicrobial in that they kill bacteria, and they may even slow the growth of tumors. However, despite goldenseals inclusion in many cold remedies, its unclear whether the effects observed in animals apply to humans. One particular study observed that goldenseal mixed with myrrh and thyme helped treat oral herpes (30, 31). View abstract. National Library of Medicine: MedlinePlus. View abstract. The plant group Echinacea is made up of several different kinds or species, all occurring east of the Rocky mountains, though they are increasingly cultivated in Oregon and California. View abstract. Yes. International Journal of Endocrinology. As such, this herbal supplement may slow the detox process rather than promote it (1, 17). Kim, W. S., Lee, Y. S., Cha, S. H., Jeong, H. W., Choe, S. S., Lee, M. R., Oh, G. T., Park, H. S., Lee, K. U., Lane, M. D., and Kim, J. Budzinski JW, Foster BC, Vandenhoek S, Arnason JT. Phytomedicine 2000;7:273-82. Goldenseal contains berberine, which might decrease how quickly the body breaks down dextromethorphan. Infect Immun. View abstract. View abstract. The objective of a study published by Global Advances in Health and Medicine was to determine the remission rate of SIBO using an antibiotic versus an herbal remedy. Journal of the Indian Medical Association 1967;48(1):1-11. View abstract. View abstract. Repeated administration of berberine inhibits cytochromes P450 in humans. Hayasaka, S., Kodama, T., and Ohira, A. Jalloh MA, Gregory PJ, Hein D, et al. Goldenseal might decrease the amount of metformin in the body. Khin, Maung U. and Nwe, Nwe Wai. Taking goldenseal with digoxin might cause slight increases in digoxin levels in the body. Goldenseal gets its name from the golden-yellow scars that form on the base of the stem when it is broken. Goldenseal is considered safe when consumed for short periods at the typically recommended dosages. Kaneda Y, Torii M, Tanaka T, and et al. 2005 - 2023 WebMD LLC, an Internet Brands company. Anticancer Res 2005;25(6B):4053-4059. Instead, these products contain other ingredients not listed on the label. Lu, S. S., Yu, Y. L., Zhu, H. J., Liu, X. D., Liu, L., Liu, Y. W., Wang, P., Xie, L., and Wang, G. J. Berberine promotes glucagon-like peptide-1 (7-36) amide secretion in streptozotocin-induced diabetic rats. Berberine in goldenseal may slightly lower blood glucose (sugar) in people with diabetes. J Cardiovasc Pharmacol 1985;7(2):307-315. This includes the virus responsible for the common cold (7, 8, 9, 10, 11). 2. Gurley BJ, Swain A, Hubbard MA, et al. Goldenseal (Hydrastis canadensis), also known as orange root, yellow root or yellow puccoon, is a perennial herb belonging to the buttercup family, Ranunculaceae. It contains potent anti-bacterial, anti-microbial, anti-fungal, and anti-inflammatory properties as well as . WebMD does not provide medical advice, diagnosis or treatment. Jpn.J Pharmacol 1970;20(4):482-487. Clin Exp.Pharmacol Physiol 2012;39(5):406-411. Goldenseal is a good source of vitamins A, C, E, & B-complex and minerals such as calcium, iron and manganese. This is not surprising since berberine has shown antimicrobial activity against certain pathogens that cause bacterial diarrhea, including E. coli and V. cholera as shown by a randomized controlled clinical trial back in 1987 involving 165 adults with acute diarrhea due to those two bacterial offenders. Thank you, {{form.email}}, for signing up. Hong, Y., Hui, S. S., Chan, B. T., and Hou, J. When in doubt, contact your healthcare provider or local poison control helpline. It is a low, sprawling plant native to the rich, shady soil of the deciduous forests of North America growing from southern Quebec to northern Georgia and west to Missouri. According to the World Health Organization (WHO), infections with C. jejuni are the most common cause of gastroenteritis (38). For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version. Phytomedicine. 5 Health Benefits of Goldenseal. eases sore throat. It contains berberine, which has been used in Traditional Chinese Medicine (TCM), for thousands of years to treat dysentery and infectious diarrhea. The scientific name for goldenseal is Hydrastis Canadensis L. Another name for goldenseal is yellow root. Evidence Based. Scazzocchio F, Corneta MF, Tomassini L, Palmery M. Antibacterial activity of Hydrastis canadensis extract and its major isolated alkaloids. 4 Natural Supplements That Are as Powerful as Drugs, 10 Delicious Herbs and Spices With Powerful Health Benefits, 10 Books That Shine a Light on Complementary and Alternative Medicine, Debra Rose Wilson, Ph.D., MSN, R.N., IBCLC, AHN-BC, CHT, Why Home Remedies for Chlamydia Are a Bad Idea, 6 Home Remedies for Urinary Tract Infections (UTIs), Debra Sullivan, Ph.D., MSN, R.N., CNE, COI, UTIs in Adults: Everything You Need to Know. Goldenseal is a perennial herb that's native to the eastern United States. [Antidiarrheal and anti-inflammatory effects of berberine]. J Ethnopharmacol. They can also ensure youre giving goldenseal a good trial at appropriate doses. 2000;87(5):218-222. View abstract. Its roots and leaves have been used in traditional medicine to treat a variety of ailments, especially those involving infections or inflammation (1). Planta Med 2001;67:561-4. J Infect Dis 1987;155:979-84. Mol Cancer Ther 2006;5(2):296-308. Gurley BJ, Gardner SF, Hubbard MA, et al. 5 Health Benefits of Goldenseal. View abstract. Zhang, H., Wei, J., Xue, R., Wu, J. D., Zhao, W., Wang, Z. When possible, choose a supplement tested by a trusted third party, such as USP, ConsumerLabs, or NSF. Increased production of antigen-specific immunoglobulins G and M following in vivo treatment with the medicinal plants Echinacea angustifolia and Hydrastis canadensis. View abstract. Traditionally, Native Americans used goldenseal to treat a variety of health problems, including sore or itchy eyes, mouth ulcers, and even tuberculosis. View abstract. Children who grow up with this disease often have lifelong symptoms, including difficulty speaking, learning disabilities, hearing loss, and more.. Berberine in the treatment of diarrhoea of infancy and childhood. 9 essential traits of a good husband. View abstract. Clinical trials with berberine hydrochloride for the control of diarrhea in acute gastroenteritis. Read our. In addition, short-term use is poorly defined, and little is known about the safety of long-term use or high dosages (1, 42). Serious side effects may include: Severe allergic reaction: A severe allergic reaction is a possible serious side effect of any medication. Scientific research suggests that medicinal plants like goldenseal and, research at the University of Texas-Houston Medical School, There havent been any clinical (human) studies to date, but goldenseal is also sometimes recommended to treat, For example, one in vitro study published in the journal, berberine inhibited the growth of breast cancer cells to a greater extent than doxorubicin, Berberine alkaloids have also been shown during in vivo studies to have potent cancer cell killing activity against tumor cells. What Happens if I Take Too Much Goldenseal? Traditionally, herbal medicine practitioners use goldenseal paired with other herbs like echinacea, myrrh, and St. John's Wort to help symptoms of herpes outbreaks. Little scientific guidance can be found regarding the optimal handling and storage of goldenseal supplements. Well-designed studies in humans are necessary to evaluate goldenseal's effects on canker sores better. When left untreated, chlamydia can cause various complications, including infertility. For external use, there is no standard recommended dosage, but read the label of the topical product for instructions. View abstract. Over-the-counter goldenseal preparations tend to be available in doses ranging from 100470 mg, and most people seem to take goldenseal in doses of 0.510 grams or 0.310 mL three times a day (1). However, even if supplements are third-party tested, that doesn't mean they are necessarily safe for all or effective in general. Therefore, talking to your healthcare provider about any supplements you plan to take and checking in about potential interactions with other supplements or medications is important. (14), An animal model study published in the Journal of Lipid Research also demonstrates that the root extract is highly effective in regulation of the livers LDL (bad cholesterol) receptors and in reducing plasma cholesterol. J Endocrinol. Coughlan KA, Valentine RJ, Ruderman NB, Saha AK. View abstract. Indian J Ophthalmol. View abstract. Yet, no studies have observed these effects directly in humans. Metabolism 2010;59(2):285-292. It is used as antiseptic for cuts, wounds, burns, skin itching, dermatitis, herpes blisters, canker sores, gum inflammation, dandruff, ring worms, cold sores, athlete's foot and other skin diseases. J Clin Pharmacol 2003;43:1283-8.. View abstract. Overall, the findings identified goldenseal as a natural LDL-lowering agent. Berberine sulfate blocks adherence of Streptococcus pyogenes to epithelial cells, fibronectin, and hexadecane. 3 If you have excessively low blood sugar, symptoms may . Lin, J. P., Yang, J. S., Lee, J. H., Hsieh, W. T., and Chung, J. G. Berberine induces cell cycle arrest and apoptosis in human gastric carcinoma SNU-5 cell line. Herpes is a viral infection that causes watery blisters on the skin or mucous membranes of the lips, mouth, or genitalia. There is currently limited research to support goldenseal for any health benefits. Immunol Lett 1999;68:391-5. Peng, W. H., Hsieh, M. T., and Wu, C. R. Effect of long-term administration of berberine on scopolamine-induced amnesia in rats. J Pharm Sci. Lin, C. C., Kao, S. T., Chen, G. W., Ho, H. C., and Chung, J. G. Apoptosis of human leukemia HL-60 cells and murine leukemia WEHI-3 cells induced by berberine through the activation of caspase-3. Berberis artistata inhibits PAF induced aggregation of rabbit platelets. Drug Metab Dispos 2004;32:405-12. . Interference of herbal drinks with urinalysis for drugs of abuse. Wang, D. Y., Yeh, C. C., Lee, J. H., Hung, C. F., and Chung, J. G. Berberine inhibited arylamine N-acetyltransferase activity and gene expression and DNA adduct formation in human malignant astrocytoma (G9T/VGH) and brain glioblastoma multiforms (GBM 8401) cells. One study showed that using high amounts of berberine, one of the antimicrobial or bacteria-killing components of goldenseal, may damage the cells on the surface of the eye lens. Zhu, B. and Ahrens, F. Antisecretory effects of berberine with morphine, clonidine, L- phenylephrine, yohimbine or neostigmine in pig jejunum. Most of goldenseals purported health effects are attributed to its active compounds berberine, hydrastine, and canadine. Goldenseal extracts also appear effective against the C. jejuni bacterium, which is a main cause of gastroenteritis (37). AMPK activation: a therapeutic target for type 2 diabetes? For best results, follow the storage and handling recommendations outlined on your products packaging and make sure to discard products that have passed their expiration date. View abstract. Unlike many supplements and foods, with average dosage sizes you don't hear of the common adverse reactions like headache, nausea, vomiting, diarrhea, fatigue, and so forth. This study also showed no serious negative effects from using berberine in this manner. (2, 3, 4, 5) It has also gained popularity after a rumor spread that taking the herb can help block a positive test for illegal drugs. Goldenseal might slow blood clotting. Zhu B and Ahrens FA. Tripathi YB and Shukla SD. Rehman J, Dillow JM, Carter SM, et al. If you take digoxin, talk to your healthcare provider before taking goldenseal. Animal testing confirms that goldthread can soothe redness, swelling, and irritation. Supplement use should be individualized and vetted by a healthcare professional, such as a registered dietitian, pharmacist, or healthcare provider. The plant grows in the northern areas of North America and is at risk of over-picking. The combination is effective since goldenseal owns the ability to treat the infection which is the main cause of sore throat. Li XB. Moreover, the combination of berberine with blood-sugar-lowering medication appears to be more effective than taking blood-sugar-lowering medications on their own (47). Tims M. Botanical adulternants bulletin on adulteration of Hydrastis canadensis root and rhizome. Kuo, C. L., Chou, C. C., and Yung, B. Y. Berberine complexes with DNA in the berberine-induced apoptosis in human leukemic HL-60 cells. View abstract. Lee, Y. S., Kim, W. S., Kim, K. H., Yoon, M. J., Cho, H. J., Shen, Y., Ye, J. M., Lee, C. H., Oh, W. K., Kim, C. T., Hohnen-Behrens, C., Gosby, A., Kraegen, E. W., James, D. E., and Kim, J. Life Sci. People currently taking medications should consult their healthcare provider before starting to take goldenseal. Pregnancy: According to the National Center for Complementary and Integrative Health (NCCIH), pregnant people shouldn't use goldenseal. Mohan, M., Pant, C. R., Angra, S. K., and Mahajan, V. M. Berberine in trachoma. Older test-tube studies suggest that berberine, one of the main active compounds in goldenseal, may help fight P. acnes, the bacterium responsible for acne (32). 1982;76 Suppl:83-88. Its scientific name is Hydrastis canadensis (H. canadensis). View abstract. For the powdered root and rhizome, four to six grams per day in tablet or capsule form is sometimes recommended. In vivo effects of goldenseal, kava kava, black cohosh, and valerian on human cytochrome P450 1A2, 2D6, 2E1, and 3A4/5 phenotypes. Oncology 1986;43:131-4. Study of some pharmacological actions of berberine. MedGenMed 2001;3:3. 2012;68(2):213-217. doi: 10.1007%2Fs00228-011-1108-2. That said, few of these studies looked at the direct effects of goldenseal in humans, and no recent research can be found to support these older findings. 4-10-2001;165(1):35-42. Relationship between the clinical effects of berberine on severe congestive heart failure and its concentration in plasma studied by HPLC. There's evidence that berberine may help lower high LDL, total cholesterol and high blood pressure levels. View abstract. Taking goldenseal while taking dextromethorphan might increase the effects and side effects of dextromethorphan. As goldenseal has generally antimicrobial properties, studies show that its useful in treating microbial, or bacterial, diarrhea and gastritis. Lin, S., Tsai, S. C., Lee, C. C., Wang, B. W., Liou, J. Y., and Shyu, K. G. Berberine inhibits HIF-1alpha expression via enhanced proteolysis. (1). Goldenseal is a North American herb. View abstract. In vitro effects of berberine sulphate on the growth and structure of Entamoeba histolytica, Giardia lamblia and Trichomonas vaginalis. Goldenseal might change how quickly the liver breaks down these medications. Goldenseal is praised for its antibacterial and anti-inflammatory properties. Goldenseal is available in several different dosage formswith capsules likely being the most common. Dietary supplement interactions with antiretrovirals: a systematic review. B. Pharmacological actions of berberine on the central nervous system. Treatment of chloroquine-resistant malaria using pyrimethamine in combination with berberine, tetracycline or cotrimoxazole. . The dried root is very commonly used in supplements in the US. Zeng XH, Zeng XJ, Li YY. 2015;161:69-81. Goldenseal contains berberine which is responsible for many of its impressive health benefits. Jiang XW, Zhang Y, Zhu YL, et al. View abstract. Detailed study of berberine. That said, no studies can currently confirm whether these dosages are the most beneficial ones. Influence of goldenseal root on the pharmacokinetics of indinavir. People wishing to try goldenseal should carefully read a supplements ingredient label to ensure that it truly contains goldenseal before purchasing the product. Goldenseal is available in various forms, including capsules and tablets. The dried root is very commonly used in, There isn't enough reliable information to know what an appropriate dose of goldenseal might be. Z., Wang, S. K., Zhou, Z. X., Song, D. Q., Wang, Y. M., Pan, H. N., Kong, W. J., and Jiang, J. D. Berberine lowers blood glucose in type 2 diabetes mellitus patients through increasing insulin receptor expression. Chatterjee P, Franklin MR. Human cytochrome p450 inhibition and metabolic-intermediate complex formation by goldenseal extract and its methylenedioxyphenyl components. Goldenseal has become one of the top selling herbs of North America. View abstract. Available at: https://cms.herbalgram.org/BAP/BAB/BAP-BABs-Goldenseal-v4.pdf (Accessed 30 March 2017). Animal studies suggest that berberine, one of the main active compounds in goldenseal, is linked to lower weight in both mothers and babies. Our team aims to be not only thorough with its research, but also objective and unbiased. Symptoms may include breathing difficulties, itchiness, and rash. Excessively low blood sugar symptoms may include tremors, sweating, and rapid heartbeat. Goldenseal may pose risks in the following situations: Severe allergic reaction: Avoid goldenseal if you have a severe allergic reaction to it or its components (parts or ingredients). Cardiovasc Drug Rev 2001;19(3):234-244. boosts the immune system.
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